Adult T-cell Leukemia/Lymphoma (ATL) in Japan
نویسندگان
چکیده
منابع مشابه
Adult T-Cell Leukemia/Lymphoma (ATL): Pathogenesis, Treatment and Prognosis
Adult T-cell leukemia/lymphoma (ATL) was first described in 1977 as a distinct clinico‐ pathological entity with a suspected viral etiology. Subsequently, a RNA retrovirus, hu‐ man T-cell leukemia /lymphotropic virus type 1 (HTLV-1) was isolated as a carcinogenic pathogens [1]. HTLV-1 infects approximately 15 to 20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa...
متن کاملHuman T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)
The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only ...
متن کاملPossible roles of an adult T-cell leukemia (ATL)-derived factor/thioredoxin in the drug resistance of ATL to adriamycin.
Chemotherapy for adult T-cell leukemia (ATL) has been reported to fail to induce complete remission because of drug resistance in most patients. We have examined the expression of an ATL-derived factor (ADF)/thioredoxin in relation to resistance to adriamycin (ADM) in various T-cell leukemia cell lines including ATL cell lines. Immunoblot analysis demonstrated that ATL cell lines expressed ADF/...
متن کاملSpecific cutaneous manifestations in adult T cell leukemia/lymphoma
Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
متن کاملProduction of interleukin 1 by adult T cell leukemia (ATL) cell lines.
The accessory function for T cell activation and the production of interleukin 1 (IL 1) of adult T cell leukemia (ATL) cell lines were studied in vitro. ATL cell lines such as Hut-102, MT-1, and MT-2 functioned as accessory cells for the stimulation of human T cell proliferative response induced with concanavalin A (Con A) and induced allogeneic mixed lymphocyte reaction. Cell lysates of three ...
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ژورنال
عنوان ژورنال: Journal of Epidemiology
سال: 1992
ISSN: 0917-5040
DOI: 10.2188/jea.2.2sup_63